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Meantime, hepatic and renal function biochemical markers tests exhibited normal ranges of values in the PBS, Gi-F-CAA (8 mg/kg in 100 L PBS), Gi-F-CAA (12 mg/kg in 100 L PBS) and Gi-F-CAA (16 mg/kg in 100 L PBS) treatment groups at 1 day post-injection, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea nitrogen (BUN), and creatinine (CRE) levels (Supplementary Fig

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This growing awareness has inspired two complementary approaches: Designing microbiome-targeted products that actively modulate its composition or function Developing microbiome-friendly formulations that preserve the natural balance and integrity of the skin microbiota Why Does This Matter

Additionally, the extravasation of immune cells, particularly neutrophils and monocytes, further amplifies the astrocyte activation process through the release of proinflammatory cytokines and chemokines (54)

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